Physiological and Histological Study of the Therapeutic Effect of Silibinin on Testicular Alteration in Adult Male Albino Rats

The male reproductive system is vulnerable to oxidative stress, which linked several disorders. Silibinin, a natural polyphenolic flavonoid, possesses antioxidant, anti-inflammation and anticancer properties. Considering silibinin's wide range of biological metabolic roles (silibinin) plays, the current study was conducted evaluate biochemical, histological, immunohistochemical morphometric changes that may develop in rat testis exposed stress possible protective role silibinin. Thirty adult rats were used study. Rats equally divided into three groups. G1 negative control group, G2 given thioacetamide (200 mg/kg body weight, G3 received silibinin at (100 weight) for 4 w concurrently with thioacetamide. Serum levels sexual hormones testicular markers measured. Testicular sections stained haematoxylin eosin, stains Vimentin p53 subjected statistical analysis. histological architecture biochemical all declined group. When silibinin, however, normal parameters restored structure their testicles preserved. This investigation showed might increase testosterone gonadotropin enhance indices (luteinizing hormone follicle-stimulating hormone). effects on toxicity evidenced by antioxidant activities improvement structures both Leydig Sertoli cells. As result, it can be as supplement improve function, particularly spermatogenesis.